منابع مشابه
Myocardin-related transcription factor-A: mending a broken heart.
Ventricular remodeling following myocardial infarction (MI) is a complex process driven by the response of both the myocytic and the nonmyocytic components of the heart to dynamic mechanical and neurohumoral stimuli. Despite the advent of reperfusion therapy and the administration of drugs slowing the progression of heart failure, many patients experiencing a MI undergo a progressive decline in...
متن کاملMyocardin-related transcription factor A mediates OxLDL-induced endothelial injury.
RATIONALE Atherosclerosis proceeds through a multistep reaction that begins with endothelial injury caused by a host of stress signals, among which oxidized low-density lipoprotein (oxLDL) plays a critical role. OxLDL disrupts normal functionality of the endothelium by upregulating adhesion molecules (eg, ICAM-1) and concomitantly downregulating endothelial nitric oxide synthase (eNOS) expressi...
متن کاملMyocardin-related transcription factor A cooperates with brahma-related gene 1 to activate P-selectin transcription
Expression of P-selectin in injured or activated endothelia cells serves as a permissive step towards leukocyte recruitment and perpetuation of inflammation in the pathogenesis of atherosclerosis. P-selectin can be induced by pro-inflammatory stimuli via the transcription factor NF-kB, but the epigenetic mechanisms remain incompletely understood. Previously we reported that myocardin-related tr...
متن کاملA Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis
In scleroderma (systemic sclerosis, SSc), persistent activation of myofibroblast leads to severe skin and organ fibrosis resistant to therapy. Increased mechanical stiffness in the involved fibrotic tissues is a hallmark clinical feature and a cause of disabling symptoms. Myocardin Related Transcription Factor-A (MRTF-A) is a transcriptional co-activator that is sequestered in the cytoplasm and...
متن کاملA myocardin-related transcription factor regulates activity of serum response factor in Drosophila.
Serum response factor (SRF) regulates genes involved in cell proliferation, migration, cytoskeletal organization, and myogenesis. Myocardin and myocardin-related transcription factors (MRTFs) act as powerful transcriptional coactivators of SRF in mammalian cells. We describe an MRTF from Drosophila, called DMRTF, which shares high homology with the functional domains of mammalian myocardin and ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2010
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.110.224881